Botany and Plant Pathology Seminar Series
Speaker: Dr. Diane Bassham - Department of Botany - Iowa State University
Topic: Degradation of Cellular Components by Autophagy: from Molecules to Organelles
When: Wednesday, November 20, 2013 at 3:30 pm in WSLR 116

Vacuolar autophagy is a macromolecule degradation pathway in which cellular components are transported to the vacuole to recycle nutrients during nutrient deficiency and senescence and to clear damaged molecules and organelles during environmental stress. Autophagy therefore contributes to plant survival and growth during adverse environmental conditions. A major outstanding question is how autophagy is regulated under these diverse conditions. We have identified regulatory factors in the activation of autophagy, including the negative regulators TOR and RAPTOR, and have evidence that the TOR signaling pathway is involved in activating autophagy in response to stress conditions in plants. We are also analyzing potential selective autophagy pathways, in which substrates for autophagy are recognized by receptor proteins and targeted for degradation. Pathways under study include degradation of the endoplasmic reticulum during ER stress and degradation of ribosomal RNA in a ribophagy-related process.

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