Botany and Plant Pathology Seminar Series
Speaker: Dr. Israel Ausin - Centro Nacional de Biotechnologia, Madrid, Spain - Candidate for Epigenetic and Chromatin Biology Position in Botany and Plant Pathology
Topic: Uncovering New Proteins in the RdDM Pathway
When: Monday, March 25, 2013 at 9:30 pm in WSLR 116
Abstract:

DNA methylation is an epigenetic mark that is associated with the repression of genes and transposable elements. In Arabidopsis, maintenance of DNA methylation is carried out by three methyltransferases: METHYLTRANSFERASE 1 (MET1), CHROMOMETHYLASE 3 (CMT3) and DOMAINS REARRANGED METHYLTRANSFERASE2 (DRM2). However, DRM2 is solely responsible for establishment of DNA methylation—or de novo methylation—. DRM2 is guided by small interfering RNAs, (siRNAs), in a process known as RNA-directed DNA methylation (RdDM).  By a combination of genetic and biochemical  approaches, we have Isolated and characterized several proteins acting with in the RdDM pathway. The role of these new proteins will be discussed.

 

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