Hi, I am Paul, a current graduate student in Dr. Scott Briggs’s lab. I am originally from Cleveland, Ohio where I received my B.S. in biology from Ursuline College. My interests in Epigenetics, which roughly is an heritable change in gene expression without changes or mutations to the underlying DNA is what brought me to the Department of Biochemistry at Purdue University. My project is involved in understanding protein-protein interactions within the Set1 histone methyltransferase complex in Saccharomyces cerevisiae. As well as how those protein interactions affect histone H3 lysine 4 methylation and gene expression. This is important because the human homologs of Set1 are known to be associated with various types of cancers and other diseases.
Besides my interests in the lab, I also enjoy outdoor activities such as mountain biking, camping, and hiking. I also love spending time with my wife and children, playing at the park and going to places like the zoo.
Awards and Honors:
Frederick N. Andrews Fellowship, Purdue University
Poster Award Annual Biochemistry Retreat, Purdue University, West Lafayette, IN.
2010 Beach Travel Grant: For presentation of a poster, “Biological Methylation: From DNA to Histones” at the 2010 FASEB summer research conference in Carefree, Arizona in June.
Bilsland Strategic Initiatives Fellowship
Purdue Center for Cancer Research: Research Grant
Teaching Assistant for Dr. Jim Forney for Medical Biochemistry (LCME 505).
Assisted in lecture and laboratory work, grading of exams, quizzes and lab reports.
Assisted in mentoring of undergraduates and junior graduate students in Scott D. Briggs’s lab
South, P.F., Fingerman, I.M., Mersman, D.P., Du, H.-N. and Briggs, S.D. (2010). A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression. J. Biol. Chem. 285: 595-607.
Mersman, D.P., Du, H.-N., Fingerman, I.M., South, P.F. and Briggs, S.D. (2009). Polyubiquitination of the demethylase Jhd2 controls histone methylation and gene expression. Genes & Development 23: 951-962.
The Briggs' lab members visited historic Montezuma Castle near Sedona, AZ after the FASEB meeting, June 2010.
Me at the top of Black Mountian near Carefree, AZ while at the FASEB meeting, June 2010