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T. J. Kappock

Awards & Honors

(1989) American Institute of Chemists Award. Northwestern University.

(1995) Predoctoral Fellowship. Howard Hughes Medical Institute.

(1996) Wolfgang Prize for Outstanding Academic Work in Chemistry. Yale University.

(2009) NSF CAREER Award. National Science Foundation.

(2014) Program Chair, 35th Midwest Enzyme Chemistry Conference. Midwest Enzyme Chemistry Conference.

Selected Publications

Lamb, A., Kappock, T., & Silvaggi, N. (2015). You are lost without a map: Navigating the sea of protein structures. Biochim. Biophys. Acta, 1854, 258-268. Retrieved from

Hung, J., Mill, C., Clifton, S., Margrini, V., Bhide, K., Francois, J., Ransome, A., . . . Kappock, T. (2014). Draft genome sequence of Acetobacter aceti strain 1023, a vinegar factory isolate. Genome Announc, 2, (3):e00550-14. doi:10.1128/genomeA.00550-14. Retrieved from

Sullivan, K., Huma, L., Mullins, E., Johnson, M., & Kappock, T. (2014). Metal stopping reagents facilitate discontinuous activity assays of the de novo purine biosynthesis enzyme PurE. Anal. Biochem, 452, 43-45. Retrieved from

Mullins, E., Sullivan, K., & Kappock, T. (2013). Function and X-Ray crystal structure of Escherichia coli YfdE. PLoS ONE, 8, e67901. doi: 10.1371/journal.pone.0067901.

Mullins, E., & Kappock, T. (2013). Functional analysis of the acetic acid resistance (aar) gene cluster in Acetobacter aceti strain 1023. Acetic Acid Bacteria, s1, e3. Retrieved from

Mullins, E., & Kappock, T. (2012). Crystal structures of Acetobacter aceti succinyl-Coenzyme A (CoA):acetate CoA-transferase reveal specificity determinants and illustrate the mechanism used by class I CoA-transferases. Biochemistry, 42, 8422-8434.

Mullins, E., Starks, C., Francois, J., Sael, L., & Kihara, D. (2012). Formyl-coenzyme A (CoA):oxalate CoA-transferase from the acidophile Acetobacter aceti has a distinctive electrostatic surface and inherent acid stability. Protein Sci, 21, 686-696.

Perez-Jimenez, R., Ingles-Prieto, A., Zhao, Z., Sanchez-Romero, I., Alegre-Cebollada, J., & Kosuri, P. (2011). Single-molecule paleoenzymology probes the chemistry of resurrected enzymes. Nat. Struct. Mol. Biol, 18, 592-596. Retrieved from

Tranchimand, S., Starks, C., Mathews, I., & Hockings, S. (2011). Treponema denticola PurE is a bacterial AIR carboxylase. Biochemistry, 50, 4623-4637.

Kurz, L., Constantine, C., & Jiang, H. (2009). The partial substrate dethiaacetyl-coenzyme A mimics all critical carbon acid reactions in the condensation half-reaction catalyzed by Thermoplasma acidophilum citrate synthase. Biochemistry, 48, 7878-7891.