Map of substrate-kinase interactions may
lead to more effective cancer drug
By Brian Wallheimer
March 29, 2012
Later-stage cancers thrive by finding detours around roadblocks that cancer drugs put in their path, but a Purdue University biochemist is creating maps that will help drugmakers close more routes and develop better drugs.
Kinase enzymes deliver phosphates to cell proteins in a process called phosphorylation, switching a cellular function on or off. Irregularities in phosphorylation can lead to uncontrolled cell growth and are a hallmark of cancer.